I've only seen sprite comics personally, while I'm sure fully original, pixel art comics exist, I haven't been exposed.
Lots of the LGBT community are brought together online where there is/was the availability of spaces where they aren't judged for being who they are. Pixel art is pretty online focused so there's a big overlap. You see it in other online communities too, lots of digital art, furry art, speedrunning and software developer circles have LGBT overlap, for instance.
Lemme take a quick look through the reds/hearts, should be somin good